Day 1 – Tuesday, May 6
REGISTRATION AND BADGE PICKUP
CHALLENGE KICKOFF & TUTORIAL
Therapeutic Actionability AI Challenge (RECORDED)




Even after receiving a diagnosis, rare disease patients often face a daunting, arduous, multi-year therapeutic odyssey to identify plausible treatments. We are launching the Precision Therapeutics Challenge to invite participants to tackle this pressing issue by building an automated system leveraging technologies such as LLM agents to transform a patient’s genetic diagnosis into a personalized, therapeutic actionability report. Successful submissions to this competition, due in November 2025, will address a wide spectrum of therapeutic paths, from identifying approved targeted therapies to exploring drug repurposing opportunities and highlighting candidates for cutting-edge interventions like gene therapy. Join us to learn more about the challenge goals and key biomedical and technical resources that teams can leverage for this task. This session will also include a hands-on tutorial on how to use Hugging Face tools.
OPENING REMARKS
PANEL 1
The Economics of AI

Editor-in-Chief, Second Opinion




Ultimately AI services are a new expenditure in healthcare. Whether this additional expenditure gets bundled into existing services or is maintained as a supplemental and separate service will determine many of the incentives for innovation and dissemination of AI tools in healthcare. In this panel, experts from both sides of the reimbursement and value proposition for AI will discuss likely drivers in the near term perspective.
FIRESIDE CHAT
AI-Driven Drug Development


Editor-in-Chief, NEJM AI

A fireside chat with two remarkable leaders in AI-driven drug development from industry and academia about accelerating progress and remaining hurdles.
BREAK
WELCOME DINNER & REGISTRATION
Day 2 – Wednesday, May 7
BREAKFAST & LATE REGISTRATION
REMARKS
OPENING KEYNOTE
PANEL 2
Accelerating the Learning Health Systems Flywheel with AI



Director, Center for Healthcare Innovation & Delivery Science, NYU Langone Health

Director, UC San Diego Center on Learning Health Systems Science
The integration of learning health systems and artificial intelligence presents substantial opportunity to improve healthcare delivery by creating create continuous feedback loops between clinical practice and research. The goal of enabling healthcare organizations to systematically learn from every patient interaction while maintaining the highest standards of care requires innovation in data integration, workflow optimization, and organizational change management. We’ll discuss what the current state of learning health systems with particular attention to the impact of AI on their future.
QUICK BREAK
LUNCH
FIRESIDE CHAT 2
Patients Build the Future of Health AI




Healthcare revolutions of the past 50 years began with patients who refused to accept the status quo. Meet patients who have successfully sparked past revolutions to create transparent, open, and humane systems in health technology. Learn how these expert patients are using and building AI to shape the future with their communities.
COFFEE BREAK
POSTER SESSION
- Odd numbered posters from 2:45-3:45 PM
- Even numbered posters from 3:45-4:45 PM
FIRESIDE CHAT 3
Surgical AI
BREAK
DINNER BANQUET
Day 3 – Thursday, May 8
BREAKFAST
PANEL 3
How is AI Affecting the Workforce?



Large language models and other new AI-based innovations have shaken up almost every area of clinical care in a matter of just a few years. As we gain a better understanding of this ‘influx of AI’, increasingly more attention is paid to the effects it has had on the diverse roles that humans play in healthcare. In this panel, we focus on these effects that pertain to the healthcare workforce, and particularly on the nursing workforce. We hear from several of the leading figures in nursing informatics (both applied and research-oriented) and human resources officials who have seen these effects first-hand. Our discussion will include both a retrospective look at past successes and failures as well as perspectives about how AI will continue to alter the nursing workforce.
SPOTLIGHT TALK 1
SPOTLIGHT TALK 2
QUICK BREAK
YEAR IN REVIEW

Medical Director for AI, NewYork-Presbyterian
LUNCH
SPOTLIGHT TALK 3
SPOTLIGHT TALK 4
SPOTLIGHT TALK 5
INVITED TALK 2
COFFEE BREAK
INVITED TALK 3
Transforming Biomedicine with AI Physician-Scientists

Recent developments in agentic, multimodal models with strong reasoning capabilities herald the development of AI physician-scientists. This talk will discuss some of the recent progress towards this and lay out how such capable AI systems might help accelerate disease understanding, develop new cures, and make healthcare accessible to everyone, everywhere.
PANEL 4
What Should Medical Journals Be Publishing About AI?


Editor-in-Chief, NEJM AI

Professor of Dermatology, Harvard Medical School


Director, Center for Quantitative Health, MGH
Professor of Psychiatry, Harvard Medical School

What should be published in the fast moving field of AI in Medicine? How should we distinguish between checkpoints in performance as compared to clinically validated trials? Why and when should retrospective validations be reported? Hear answers and ask your own questions of editors from leading AI in medicine journals.
BREAK
DINNER BANQUET
DAY 4 – Friday, May 9
BREAKFAST
DEBATE 1
AI Transparency



Co-Lead, Health AI Partnership
AI has greatly benefited from decades of academic research projects that release code and software as open source. This allows others to verify the code and easily extend it for new purposes. However, this kind of transparency does not always exist in the healthcare space where commercial entities need to protect their intellectual property. This can limit AI software evaluation that is so important for building trust for clinical decision support. This debate will explore both sides of the AI transparency issue and its impact on patient care.
DEBATE 2
The Utility of Working with Doctors



Is it necessary for AI researchers to work with clinicians to do the most meaningful work in medical AI? Join us for this intentionally-contentious debate to hear both sides of the argument.
QUICK BREAK
PANEL 5
Build vs Buy?




CLOSING KEYNOTE
Designing Health Data Management Systems that Benefit Patients and Society

Former Professor of Surgery, Harvard Medical School
AI tools have the potential to accelerate progress in healthcare delivery and research. These tools depend upon comprehensive, accurate and timely data from the clinical care environment for their development and ongoing surveillance. This talk will address the current state of clinical data access and quality, and outline strategies that can improve our ability to acquire fit-for-purpose data for health indications.
CLOSING REMARKS
LUNCH
END OF PROGRAM
8:45-10:45 PM
OPTIONAL ON MAY 9TH: LAGUNA GRANDE BIOLUMINESCENCE KAYAK NIGHT TOUR
Join other SAIL attendees for a 2-hour kayak tour to experience the rare phenomenon of bioluminescence in Laguna Grande, one of 3 bio-bays found in Puerto Rico (and only 5 worldwide!). The glowing effect in the water is caused by dinoflagellates—microscopic organisms that emit a bluish-green neon glow in reaction to movement in the water. When planning your visit to this natural wonder, keep in mind that the glowing effect is better appreciated on dark nights, the later the better!
Plan to depart the hotel by 7:15 PM to arrive in Fajardo on time for the 8:45 PM tour. Transportation must be arranged separately.
Go to https://kayakingpuertorico.com/home/tours/bio-bay-kayak-tour/#1480108911067-bedc615c-e84b for more info and to buy tickets.
($59 per person. Children under the age of 6 are not permitted.)
9:00 AM-3:00 PM
OPTIONAL ON MAY 10TH: CULEBRA CATAMARAN & SNORKEL TOUR DAY TRIP
Join other SAIL attendees for a snorkeling and beach day trip to the famous Flamenco Beach on the island of Culebra. Snorkeling equipment and floating devices are provided, along with lunch, snacks, cocktails, beer and assorted beverages.
Plan to depart the hotel by 7:00am to arrive in Fajardo on time for the boat departure. Transportation must be arranged separately.
Go to https://eastislandpr.com/tours/culebra-island/ for more info and to buy tickets.
($142.50 per adult, $122.50 per child ages 4-11. Children under the age of 4 are not permitted. Use promo code “SAIL10” for discounted price.)